藥物交互作用
Glucarpidase + Leucovorin
嚴重程度: 嚴重
Glucarpidase and Leucovorin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Glucarpidase can hydrolyze leucovorin and its active metabolite, reducing rescue effect if given close together. Reduced rescue may worsen methotrexate toxicity.
用白話說明這項交互作用的意義
Glucarpidase and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glucarpidase belongs to Miscellaneous; Leucovorin belongs to Miscellaneous.
為什麼會發生
Glucarpidase is a carboxypeptidase that cleaves folate analogs, including leucovorin.
處置方式
Do not give leucovorin within 2 hours before or after glucarpidase. Dose leucovorin on the basis of the methotrexate concentration measured by a chromatographic method.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Glucarpidase 的其他交互作用
Leucovorin 的其他交互作用
常見問題
Can I take Glucarpidase with Leucovorin?
MediHelp rates the interaction as major. Glucarpidase and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glucarpidase can hydrolyze leucovorin and its active metabolite, reducing rescue effect if given close together. Reduced rescue may worsen methotrexate toxicity.
How serious is the interaction between Glucarpidase and Leucovorin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give leucovorin within 2 hours before or after glucarpidase. Dose leucovorin on the basis of the methotrexate concentration measured by a chromatographic method.
What other medicines interact with Glucarpidase?
MediHelp also lists interactions of Glucarpidase with, for example, Folic acid, Methotrexate, Pemetrexed. The full list is on the Glucarpidase page.
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