藥物交互作用
Mefloquine + Quinine
嚴重程度: 禁忌併用
Mefloquine and Quinine: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Both agents prolong the QT interval and mefloquine can also cause conduction abnormalities and seizures. Given together, or soon after one another, they raise the risk of serious arrhythmias and cardiac arrest.
用白話說明這項交互作用的意義
Mefloquine and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mefloquine belongs to Anti Parasitic; Quinine belongs to Anti Parasitic.
為什麼會發生
Additive QT prolongation and cardiac conduction effects (pharmacodynamic synergism).
處置方式
Avoid concurrent use; do not give mefloquine within about 12 hours after quinine. If quinine is required for severe malaria, use ECG monitoring and avoid mefloquine prophylaxis or treatment.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Quinine 的其他交互作用
Mefloquine 的其他交互作用
常見問題
Can I take Mefloquine with Quinine?
MediHelp rates the interaction as contraindicated. Mefloquine and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval and mefloquine can also cause conduction abnormalities and seizures. Given together, or soon after one another, they raise the risk of serious arrhythmias and cardiac arrest.
How serious is the interaction between Mefloquine and Quinine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; do not give mefloquine within about 12 hours after quinine. If quinine is required for severe malaria, use ECG monitoring and avoid mefloquine prophylaxis or treatment.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
