藥物交互作用

Pimozide + Quinine

嚴重程度: 禁忌併用

Pimozide and Quinine: contraindicated interaction.

最後更新 12 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Both drugs prolong the QT interval, and quinine also inhibits CYP2D6, potentially raising pimozide levels. The combination markedly raises the risk of torsades de pointes and sudden cardiac death.

用白話說明這項交互作用的意義

Pimozide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Pimozide belongs to Central Nervous System; Quinine belongs to Anti Parasitic.

證據等級: Moderate

為什麼會發生

Additive QT prolongation with quinine inhibition of CYP2D6-mediated pimozide metabolism.

處置方式

Do not co-administer; use an alternative antimalarial or antipsychotic. If quinine is essential, stop pimozide and monitor the ECG.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Pimozide 與 Quinine 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

建立免費帳號登入

在網頁版免費試用 Pro+ 14 天，無需信用卡。

常見問題

Can I take Pimozide with Quinine?

MediHelp rates the interaction as contraindicated. Pimozide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and quinine also inhibits CYP2D6, potentially raising pimozide levels. The combination markedly raises the risk of torsades de pointes and sudden cardiac death.

How serious is the interaction between Pimozide and Quinine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative antimalarial or antipsychotic. If quinine is essential, stop pimozide and monitor the ECG.

What other medicines interact with Quinine?

MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.

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摘要