藥物交互作用
Meropenem / vaborbactam + Valproic acid
嚴重程度: 禁忌併用
Meropenem / vaborbactam and Valproic acid: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Meropenem markedly reduces serum valproate concentrations, and breakthrough seizures have been reported. Vaborbactam is not the cause, but the meropenem component makes the combination hazardous.
用白話說明這項交互作用的意義
Meropenem / vaborbactam and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Carbapenems inhibit acylpeptide hydrolase, preventing hydrolysis of valproate glucuronide back to valproate, and may reduce absorption or increase red cell uptake.
處置方式
Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is essential, add alternative anticonvulsant cover and monitor valproate levels closely.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Valproic acid 的其他交互作用
常見問題
Can I take Meropenem / vaborbactam with Valproic acid?
MediHelp rates the interaction as contraindicated. Meropenem / vaborbactam and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Meropenem markedly reduces serum valproate concentrations, and breakthrough seizures have been reported. Vaborbactam is not the cause, but the meropenem component makes the combination hazardous.
How serious is the interaction between Meropenem / vaborbactam and Valproic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is essential, add alternative anticonvulsant cover and monitor valproate levels closely.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
