藥物交互作用
Meropenem + Valproic acid
嚴重程度: 禁忌併用
Meropenem and Valproic acid: contraindicated interaction.
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摘要
Meropenem causes a rapid and marked fall in serum valproic acid concentrations, often within a day or two of starting. Levels can drop below the therapeutic range, resulting in breakthrough seizures, and the effect may persist for days to weeks after the carbapenem is stopped.
用白話說明這項交互作用的意義
Meropenem and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Meropenem belongs to Anti Bacterial; Valproic acid belongs to Central Nervous System.
為什麼會發生
Carbapenems are thought to inhibit hydrolysis of valproate glucuronide back to valproate and may reduce its absorption and red cell uptake, lowering valproate concentrations.
處置方式
Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is unavoidable, add an alternative anticonvulsant, since increasing the valproate dose does not reliably overcome the effect.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Meropenem 的其他交互作用
Valproic acid 的其他交互作用
常見問題
Can I take Meropenem with Valproic acid?
MediHelp rates the interaction as contraindicated. Meropenem and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Meropenem causes a rapid and marked fall in serum valproic acid concentrations, often within a day or two of starting. Levels can drop below the therapeutic range, resulting in breakthrough seizures, and the effect may persist for days to weeks after the carbapenem is stopped.
How serious is the interaction between Meropenem and Valproic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is unavoidable, add an alternative anticonvulsant, since increasing the valproate dose does not reliably overcome the effect.
What other medicines interact with Meropenem?
MediHelp also lists interactions of Meropenem with, for example, Typhoid vaccine live, Amifampridine, Cholera vaccine. The full list is on the Meropenem page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
