藥物交互作用
Milrinone + Olprinone
嚴重程度: 嚴重
Milrinone and Olprinone: major interaction.
最後更新
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摘要
Both are phosphodiesterase-3 inhibitors with inotropic and vasodilating actions. Using them together duplicates therapy and increases the risk of hypotension and ventricular arrhythmias.
用白話說明這項交互作用的意義
Milrinone and Olprinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Duplicate PDE-3 inhibition causing additive increases in cAMP, inotropy and vasodilation.
處置方式
Avoid concurrent use; choose one PDE-3 inhibitor. If switching, stop the first before starting the second with monitoring of blood pressure and ECG.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Milrinone 的其他交互作用
常見問題
Can I take Milrinone with Olprinone?
MediHelp rates the interaction as major. Milrinone and Olprinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are phosphodiesterase-3 inhibitors with inotropic and vasodilating actions. Using them together duplicates therapy and increases the risk of hypotension and ventricular arrhythmias.
How serious is the interaction between Milrinone and Olprinone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose one PDE-3 inhibitor. If switching, stop the first before starting the second with monitoring of blood pressure and ECG.
What other medicines interact with Milrinone?
MediHelp also lists interactions of Milrinone with, for example, Anagrelide, Cilostazol, Enoximone. The full list is on the Milrinone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
