藥物交互作用
Milrinone + Riociguat
嚴重程度: 嚴重
Milrinone and Riociguat: major interaction.
最後更新
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摘要
Both drugs lower vascular resistance, milrinone through PDE3 inhibition and riociguat through soluble guanylate cyclase stimulation. Combined use may cause additive hypotension. Riociguat labeling contraindicates PDE5 inhibitors but data with other PDE inhibitors are limited.
用白話說明這項交互作用的意義
Milrinone and Riociguat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Milrinone belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
為什麼會發生
Additive vasodilation through increased cyclic AMP (PDE3 inhibition) and increased cyclic GMP (sGC stimulation).
處置方式
Monitor blood pressure closely when combining, particularly when starting or changing doses. Consider a lower riociguat starting dose and hold up-titration while on milrinone.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Milrinone 的其他交互作用
Riociguat 的其他交互作用
常見問題
Can I take Milrinone with Riociguat?
MediHelp rates the interaction as major. Milrinone and Riociguat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs lower vascular resistance, milrinone through PDE3 inhibition and riociguat through soluble guanylate cyclase stimulation. Combined use may cause additive hypotension. Riociguat labeling contraindicates PDE5 inhibitors but data with other PDE inhibitors are limited.
How serious is the interaction between Milrinone and Riociguat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely when combining, particularly when starting or changing doses. Consider a lower riociguat starting dose and hold up-titration while on milrinone.
What other medicines interact with Milrinone?
MediHelp also lists interactions of Milrinone with, for example, Anagrelide, Cilostazol, Enoximone. The full list is on the Milrinone page.
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