藥物交互作用
Natalizumab + Vedolizumab
嚴重程度: 禁忌併用
Natalizumab and Vedolizumab: contraindicated interaction.
最後更新
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摘要
Both drugs block integrin-mediated lymphocyte trafficking, natalizumab broadly including the CNS and vedolizumab selectively in the gut. Combined use may raise the risk of PML and other infections.
用白話說明這項交互作用的意義
Natalizumab and Vedolizumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Natalizumab belongs to Gastrointestinal Tract; Vedolizumab belongs to Gastrointestinal Tract.
為什麼會發生
Overlapping integrin antagonism causing additive impairment of lymphocyte trafficking.
處置方式
Do not use together. If switching, stop one agent before starting the other and monitor for infection and neurological symptoms.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Natalizumab 的其他交互作用
Vedolizumab 的其他交互作用
常見問題
Can I take Natalizumab with Vedolizumab?
MediHelp rates the interaction as contraindicated. Natalizumab and Vedolizumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs block integrin-mediated lymphocyte trafficking, natalizumab broadly including the CNS and vedolizumab selectively in the gut. Combined use may raise the risk of PML and other infections.
How serious is the interaction between Natalizumab and Vedolizumab?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. If switching, stop one agent before starting the other and monitor for infection and neurological symptoms.
What other medicines interact with Natalizumab?
MediHelp also lists interactions of Natalizumab with, for example, Axicabtagene ciloleucel, Baricitinib, Belatacept. The full list is on the Natalizumab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
