藥物交互作用
Smallpox vaccine live + Vedolizumab
嚴重程度: 嚴重
Smallpox vaccine live and Vedolizumab: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Live vaccinia vaccine can cause progressive vaccinia and other serious complications in immunocompromised patients. Vedolizumab is gut-selective, so the risk is likely lower, but its labeling advises avoiding live vaccines unless benefit outweighs risk.
用白話說明這項交互作用的意義
Smallpox vaccine live and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Theoretical impaired immune containment of replicating vaccinia virus in a patient receiving an immunomodulating biologic.
處置方式
Avoid live vaccinia vaccine during vedolizumab therapy unless exposure risk justifies it. If needed, weigh the benefit and monitor the vaccination site and for systemic vaccinia.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Vedolizumab 的其他交互作用
常見問題
Can I take Smallpox vaccine live with Vedolizumab?
MediHelp rates the interaction as major. Smallpox vaccine live and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Live vaccinia vaccine can cause progressive vaccinia and other serious complications in immunocompromised patients. Vedolizumab is gut-selective, so the risk is likely lower, but its labeling advises avoiding live vaccines unless benefit outweighs risk.
How serious is the interaction between Smallpox vaccine live and Vedolizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccinia vaccine during vedolizumab therapy unless exposure risk justifies it. If needed, weigh the benefit and monitor the vaccination site and for systemic vaccinia.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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