藥物交互作用
Upadacitinib + Vedolizumab
嚴重程度: 嚴重
Upadacitinib and Vedolizumab: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Using a JAK inhibitor with another biologic immunosuppressant increases the risk of serious infection. Vedolizumab acts mainly in the gut, so systemic effects are smaller, but combination data are limited.
用白話說明這項交互作用的意義
Upadacitinib and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Upadacitinib belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.
為什麼會發生
Additive immunosuppression via gut-selective integrin blockade and JAK inhibition.
處置方式
Avoid routine concurrent use; the upadacitinib label advises against combination with biologic immunosuppressants. If combined, monitor closely for infection.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Vedolizumab 的其他交互作用
Upadacitinib 的其他交互作用
常見問題
Can I take Upadacitinib with Vedolizumab?
MediHelp rates the interaction as major. Upadacitinib and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using a JAK inhibitor with another biologic immunosuppressant increases the risk of serious infection. Vedolizumab acts mainly in the gut, so systemic effects are smaller, but combination data are limited.
How serious is the interaction between Upadacitinib and Vedolizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use; the upadacitinib label advises against combination with biologic immunosuppressants. If combined, monitor closely for infection.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
