藥物交互作用
Nilotinib + Tinidazole
嚴重程度: 嚴重
Nilotinib and Tinidazole: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs can prolong the QT interval, and nilotinib also inhibits CYP3A4, which may raise tinidazole exposure. Tinidazole carries a labeled QT warning, so combined use may increase the risk of torsades de pointes, especially with electrolyte disturbances.
用白話說明這項交互作用的意義
Nilotinib and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Tinidazole belongs to Anti Parasitic.
為什麼會發生
Additive QT prolongation, with possible CYP3A4 inhibition by nilotinib raising tinidazole levels.
處置方式
Avoid the combination where possible; if unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tinidazole 的其他交互作用
Nilotinib 的其他交互作用
常見問題
Can I take Nilotinib with Tinidazole?
MediHelp rates the interaction as major. Nilotinib and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and nilotinib also inhibits CYP3A4, which may raise tinidazole exposure. Tinidazole carries a labeled QT warning, so combined use may increase the risk of torsades de pointes, especially with electrolyte disturbances.
How serious is the interaction between Nilotinib and Tinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
