藥物交互作用
Pexidartinib + Propylthiouracil
嚴重程度: 嚴重
Pexidartinib and Propylthiouracil: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs can cause serious liver injury, and propylthiouracil carries a boxed warning for severe hepatotoxicity. Combining them may increase the risk of hepatic injury and complicate its attribution.
用白話說明這項交互作用的意義
Pexidartinib and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Propylthiouracil belongs to Endocrine.
為什麼會發生
Additive hepatotoxicity from two hepatotoxic drugs.
處置方式
Avoid the combination where possible, using methimazole for hyperthyroidism instead; if unavoidable, monitor liver enzymes and bilirubin frequently and stop at signs of liver injury.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Propylthiouracil 的其他交互作用
Pexidartinib 的其他交互作用
常見問題
Can I take Pexidartinib with Propylthiouracil?
MediHelp rates the interaction as major. Pexidartinib and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause serious liver injury, and propylthiouracil carries a boxed warning for severe hepatotoxicity. Combining them may increase the risk of hepatic injury and complicate its attribution.
How serious is the interaction between Pexidartinib and Propylthiouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, using methimazole for hyperthyroidism instead; if unavoidable, monitor liver enzymes and bilirubin frequently and stop at signs of liver injury.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Methimazole. The full list is on the Propylthiouracil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
