藥物交互作用
Propylthiouracil + Valoctocogene roxaparvovec
嚴重程度: 嚴重
Propylthiouracil and Valoctocogene roxaparvovec: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Valoctocogene roxaparvovec commonly raises liver enzymes, and propylthiouracil is a known cause of serious liver injury. Combined use may increase hepatotoxicity risk and can complicate interpretation of enzyme rises after gene therapy.
用白話說明這項交互作用的意義
Propylthiouracil and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Propylthiouracil belongs to Endocrine; Valoctocogene roxaparvovec belongs to Miscellaneous.
為什麼會發生
Additive hepatotoxicity risk from propylthiouracil and gene therapy-related hepatocellular effects.
處置方式
Prefer an alternative antithyroid agent such as methimazole where possible. If used, monitor ALT and other liver tests frequently.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Propylthiouracil 的其他交互作用
Valoctocogene roxaparvovec 的其他交互作用
常見問題
Can I take Propylthiouracil with Valoctocogene roxaparvovec?
MediHelp rates the interaction as major. Propylthiouracil and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valoctocogene roxaparvovec commonly raises liver enzymes, and propylthiouracil is a known cause of serious liver injury. Combined use may increase hepatotoxicity risk and can complicate interpretation of enzyme rises after gene therapy.
How serious is the interaction between Propylthiouracil and Valoctocogene roxaparvovec?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antithyroid agent such as methimazole where possible. If used, monitor ALT and other liver tests frequently.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Methimazole. The full list is on the Propylthiouracil page.
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