藥物交互作用
Phenelzine + Trimipramine
嚴重程度: 禁忌併用
Phenelzine and Trimipramine: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Combining a tricyclic antidepressant with a nonselective MAOI can cause serotonin syndrome and hypertensive crisis. Reactions can be severe and life-threatening.
用白話說明這項交互作用的意義
Phenelzine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
為什麼會發生
MAO inhibition combined with tricyclic reuptake inhibition causes excess serotonergic and noradrenergic activity.
處置方式
Do not use together. Allow a washout of at least 14 days after stopping phenelzine before trimipramine, and an appropriate interval in the other direction.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Trimipramine 的其他交互作用
Phenelzine 的其他交互作用
常見問題
Can I take Phenelzine with Trimipramine?
MediHelp rates the interaction as contraindicated. Phenelzine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining a tricyclic antidepressant with a nonselective MAOI can cause serotonin syndrome and hypertensive crisis. Reactions can be severe and life-threatening.
How serious is the interaction between Phenelzine and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow a washout of at least 14 days after stopping phenelzine before trimipramine, and an appropriate interval in the other direction.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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