藥物交互作用
Prednisone + Smallpox vaccine live
嚴重程度: 禁忌併用
Prednisone and Smallpox vaccine live: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
The live vaccinia vaccine can cause progressive vaccinia or generalized infection in immunosuppressed patients, and prednisone also weakens the immune response to it. The result can be severe vaccine-related disease and reduced protection.
用白話說明這項交互作用的意義
Prednisone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Corticosteroid-induced immunosuppression permits uncontrolled replication of live vaccinia virus and reduces vaccine response.
處置方式
Avoid replicating vaccinia vaccine in patients on immunosuppressive prednisone doses; use a non-replicating vaccine if one is available and indicated. Defer vaccination until steroids have been stopped for an adequate interval, unless the exposure risk is high.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Prednisone 的其他交互作用
常見問題
Can I take Prednisone with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Prednisone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live vaccinia vaccine can cause progressive vaccinia or generalized infection in immunosuppressed patients, and prednisone also weakens the immune response to it. The result can be severe vaccine-related disease and reduced protection.
How serious is the interaction between Prednisone and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid replicating vaccinia vaccine in patients on immunosuppressive prednisone doses; use a non-replicating vaccine if one is available and indicated. Defer vaccination until steroids have been stopped for an adequate interval, unless the exposure risk is high.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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