藥物交互作用
Mifepristone + Prednisone
嚴重程度: 禁忌併用
Mifepristone and Prednisone: contraindicated interaction.
最後更新
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摘要
Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids this may precipitate adrenal insufficiency or loss of disease control, and labeling for the abortion indication lists chronic corticosteroid therapy as a contraindication.
用白話說明這項交互作用的意義
Mifepristone and Prednisone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mifepristone belongs to Endocrine; Prednisone belongs to Endocrine.
為什麼會發生
Mifepristone antagonizes glucocorticoid receptors, opposing the effect of prednisone.
處置方式
Do not use mifepristone in patients on long-term corticosteroid therapy. If a patient needs both, an alternative strategy should be selected by a specialist, since usual steroid doses may be ineffective.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Prednisone 的其他交互作用
Mifepristone 的其他交互作用
常見問題
Can I take Mifepristone with Prednisone?
MediHelp rates the interaction as contraindicated. Mifepristone and Prednisone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids this may precipitate adrenal insufficiency or loss of disease control, and labeling for the abortion indication lists chronic corticosteroid therapy as a contraindication.
How serious is the interaction between Mifepristone and Prednisone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use mifepristone in patients on long-term corticosteroid therapy. If a patient needs both, an alternative strategy should be selected by a specialist, since usual steroid doses may be ineffective.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Radium-223 dichloride. The full list is on the Prednisone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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