藥物交互作用
Risankizumab + Upadacitinib
嚴重程度: 嚴重
Risankizumab and Upadacitinib: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Risankizumab blocks IL-23 and upadacitinib inhibits JAK signaling. They are sometimes considered together in inflammatory bowel disease, but combined immunosuppression may increase infection risk and data on safety are limited.
用白話說明這項交互作用的意義
Risankizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Risankizumab belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.
為什麼會發生
Additive immunosuppression through IL-23 blockade and JAK inhibition.
處置方式
Avoid routine combination; if used, screen for tuberculosis and hepatitis beforehand and monitor for infections.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Upadacitinib 的其他交互作用
Risankizumab 的其他交互作用
常見問題
Can I take Risankizumab with Upadacitinib?
MediHelp rates the interaction as major. Risankizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Risankizumab blocks IL-23 and upadacitinib inhibits JAK signaling. They are sometimes considered together in inflammatory bowel disease, but combined immunosuppression may increase infection risk and data on safety are limited.
How serious is the interaction between Risankizumab and Upadacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if used, screen for tuberculosis and hepatitis beforehand and monitor for infections.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
