藥物交互作用
Tetracycline + Typhoid vaccine live
嚴重程度: 嚴重
Tetracycline and Typhoid vaccine live: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Oral live attenuated typhoid vaccine (Ty21a) is a viable bacterial strain that antibiotics can inactivate, reducing the immune response and protection. Tetracyclines are active against Salmonella, so vaccine failure is possible.
用白話說明這項交互作用的意義
Tetracycline and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Antibacterial activity kills or inhibits the live attenuated Salmonella strain, reducing colonisation and immunogenicity.
處置方式
Avoid antibiotics from at least 3 days before until after completing the vaccine course, per labeling. If antibiotics are required, delay vaccination or use the inactivated injectable vaccine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tetracycline 的其他交互作用
常見問題
Can I take Tetracycline with Typhoid vaccine live?
MediHelp rates the interaction as major. Tetracycline and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live attenuated typhoid vaccine (Ty21a) is a viable bacterial strain that antibiotics can inactivate, reducing the immune response and protection. Tetracyclines are active against Salmonella, so vaccine failure is possible.
How serious is the interaction between Tetracycline and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antibiotics from at least 3 days before until after completing the vaccine course, per labeling. If antibiotics are required, delay vaccination or use the inactivated injectable vaccine.
What other medicines interact with Tetracycline?
MediHelp also lists interactions of Tetracycline with, for example, Acitretin, Methoxyflurane, Isotretinoin. The full list is on the Tetracycline page.
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