藥物交互作用
Isotretinoin + Tetracycline
嚴重程度: 嚴重
Isotretinoin and Tetracycline: major interaction.
最後更新 來源: US FDA label
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摘要
Both isotretinoin and tetracycline-class antibiotics can cause benign intracranial hypertension (pseudotumor cerebri). Used together, the risk of headache, visual disturbance, and papilledema may be increased, with a risk of permanent visual loss if unrecognized. The isotretinoin label advises against concomitant use.
用白話說明這項交互作用的意義
Isotretinoin and Tetracycline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isotretinoin belongs to Dermatology; Tetracycline belongs to Anti Bacterial.
為什麼會發生
Additive pharmacodynamic effect on raising intracranial pressure; the exact mechanism of each drug is not fully established.
處置方式
Avoid concomitant use; if an antibiotic is needed during isotretinoin therapy, choose a non-tetracycline option. If the patient must stop tetracycline, allow it to be discontinued before isotretinoin starts.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Isotretinoin 的其他交互作用
Tetracycline 的其他交互作用
常見問題
Can I take Isotretinoin with Tetracycline?
MediHelp rates the interaction as major. Isotretinoin and Tetracycline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both isotretinoin and tetracycline-class antibiotics can cause benign intracranial hypertension (pseudotumor cerebri). Used together, the risk of headache, visual disturbance, and papilledema may be increased, with a risk of permanent visual loss if unrecognized. The isotretinoin label advises against concomitant use.
How serious is the interaction between Isotretinoin and Tetracycline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; if an antibiotic is needed during isotretinoin therapy, choose a non-tetracycline option. If the patient must stop tetracycline, allow it to be discontinued before isotretinoin starts.
What other medicines interact with Isotretinoin?
MediHelp also lists interactions of Isotretinoin with, for example, Demeclocycline, Minocycline, Oxytetracycline. The full list is on the Isotretinoin page.
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