Drug reference
ambrisentan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Miscellaneous (Miscellaneous)
Mechanism of action
High affinity endothelin (ETa) receptor subtype antagonist, resulting in inhibition of vasoconstriction
Two receptor subtypes, ETA and ETB, mediate the effects of ET-1 in the vascular smooth muscle and endothelium
Common side effects
- Constipation
- Palpitation
- Headaches
- Nasal Congestion
- Peripheral edema
Boxed warnings
- Do not administer ambrisentan to a pregnant female because it may cause fetal harm Females of reproductive potential: Exclude pregnancy before starting treatment, monthly during treatment, and 1 month after stopping treatment Prevent pregnancy during treatment and for 1 month after stopping treatment by using acceptable methods of contraception For all female patients, Letairis is available only through a restricted program called the Letairis Risk Evaluation and Mitigation Strategy (REMS)
Contraindications
- Pregnancy
- Idiopathic pulmonary fibrosis
Related conditions
Frequently asked questions
What drug class is ambrisentan?
ambrisentan belongs to: Miscellaneous.
How does ambrisentan work?
High affinity endothelin (ETa) receptor subtype antagonist, resulting in inhibition of vasoconstriction Two receptor subtypes, ETA and ETB, mediate the effects of ET-1 in the vascular smooth muscle and endothelium
What are the common side effects of ambrisentan?
Constipation, Palpitation, Headaches, Nasal Congestion, Peripheral edema
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