Drug interactions
Ambrisentan + Clarithromycin
Severity: Minor
Ambrisentan and Clarithromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may modestly increase ambrisentan exposure, but the effect is not considered clinically significant in labeling. Ambrisentan is metabolized by several routes including glucuronidation, which limits the impact.
What this interaction means in plain words
Ambrisentan and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Clarithromycin belongs to Anti Bacterial.
Why it happens
Clarithromycin inhibits CYP3A4 and P-glycoprotein, which are minor contributors to ambrisentan disposition.
What to do
No dose adjustment is needed; monitor for ambrisentan adverse effects such as edema, headache and hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Dexamethasone Minor
Frequently asked questions
Can I take Ambrisentan with Clarithromycin?
MediHelp rates the interaction as minor. Ambrisentan and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin may modestly increase ambrisentan exposure, but the effect is not considered clinically significant in labeling. Ambrisentan is metabolized by several routes including glucuronidation, which limits the impact.
How serious is the interaction between Ambrisentan and Clarithromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for ambrisentan adverse effects such as edema, headache and hypotension.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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