Drug interactions
Ambrisentan + Erythromycin
Severity: Minor
Ambrisentan and Erythromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may modestly increase ambrisentan exposure through transporter inhibition. The effect is small and unlikely to be clinically important, though adverse effects such as edema, headache and anemia could be slightly more likely.
What this interaction means in plain words
Ambrisentan and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Erythromycin belongs to Anti Bacterial.
Why it happens
Possible inhibition of P-glycoprotein-mediated efflux of ambrisentan by erythromycin.
What to do
No dose adjustment is usually needed; monitor for edema and hemoglobin changes during long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ambrisentan and Erythromycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Erythromycin?
MediHelp rates the interaction as minor. Ambrisentan and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin may modestly increase ambrisentan exposure through transporter inhibition. The effect is small and unlikely to be clinically important, though adverse effects such as edema, headache and anemia could be slightly more likely.
How serious is the interaction between Ambrisentan and Erythromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for edema and hemoglobin changes during long-term use.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
