Drug interactions
Ambrisentan + Dronedarone
Severity: Minor
Ambrisentan and Dronedarone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits P-glycoprotein, which is involved in ambrisentan transport, but no clinically meaningful rise in ambrisentan exposure is expected. The interaction is of limited clinical significance.
What this interaction means in plain words
Ambrisentan and Dronedarone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits P-glycoprotein, with a minor effect on ambrisentan disposition.
What to do
No dose adjustment is usually required; monitor for peripheral edema and hypotension as part of routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Dronedarone?
MediHelp rates the interaction as minor. Ambrisentan and Dronedarone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone inhibits P-glycoprotein, which is involved in ambrisentan transport, but no clinically meaningful rise in ambrisentan exposure is expected. The interaction is of limited clinical significance.
How serious is the interaction between Ambrisentan and Dronedarone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for peripheral edema and hypotension as part of routine care.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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