Drug interactions
Ambrisentan + Carbamazepine
Severity: Minor
Ambrisentan and Carbamazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong enzyme inducer and could lower ambrisentan concentrations. A strong inducer such as rifampicin did not produce a clinically meaningful change, so any effect is probably small.
What this interaction means in plain words
Ambrisentan and Carbamazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Carbamazepine belongs to Central Nervous System.
Why it happens
Possible induction of ambrisentan metabolism (CYP3A4, UGT) by carbamazepine.
What to do
No routine dose adjustment is needed. Monitor clinical response in pulmonary arterial hypertension if carbamazepine is added.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Clarithromycin Minor
- Ambrisentan + Dexamethasone Minor
Frequently asked questions
Can I take Ambrisentan with Carbamazepine?
MediHelp rates the interaction as minor. Ambrisentan and Carbamazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine is a strong enzyme inducer and could lower ambrisentan concentrations. A strong inducer such as rifampicin did not produce a clinically meaningful change, so any effect is probably small.
How serious is the interaction between Ambrisentan and Carbamazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Monitor clinical response in pulmonary arterial hypertension if carbamazepine is added.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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