Drug reference
avanafil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Genitourinary (Vasodilator)
Mechanism of action
Avanafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for the degradation of cGMP in the corpus cavernosum located around the penis. Sexual arousal results in the local release of nitric oxide, which in turn stimulates the enzyme guanylate cyclase to produce cGMP. Duration of action: ~ 6 hours.
Common side effects
- Nasopharyngitis
- Headache
- Back pain
- Nasal congestion
Contraindications
- Hypersensitivity Soluble guanylate cyclase (sGC) stimulators (eg, riociguat or vericiguat); concomitant use can cause hypotension Coadministration with nitrates Coadministration with nitrates (either regularly and/or intermittently) and nitric oxide donors Consistent with the effects of P…
Known interactions (13)
- avanafil + clarithromycin Contraindicated
- avanafil + isosorbide dinitrate Contraindicated
- avanafil + isosorbide mononitrate Contraindicated
- avanafil + itraconazole Contraindicated
- avanafil + ketoconazole Contraindicated
- avanafil + nitroglycerin Contraindicated
- avanafil + posaconazole Contraindicated
- avanafil + sodium nitroprusside Contraindicated
- avanafil + voriconazole Contraindicated
- avanafil + chloramphenicol Moderate
- avanafil + imatinib Moderate
- avanafil + isoniazid Moderate
- avanafil + nicardipine Moderate
Related conditions
Frequently asked questions
What drug class is avanafil?
avanafil belongs to: Genitourinary.
How does avanafil work?
Avanafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for the degradation of cGMP in the corpus cavernosum located around the penis. Sexual arousal results in the local release of nitric oxide, which in turn stimulates the enzyme guanylate cyclase to produce cGMP. Duration of action: ~ 6 hours.
What are the common side effects of avanafil?
Nasopharyngitis, Headache, Back pain, Nasal congestion
Which drugs interact with avanafil?
clarithromycin, isosorbide dinitrate, isosorbide mononitrate, itraconazole, ketoconazole, nitroglycerin, posaconazole, sodium nitroprusside, voriconazole, chloramphenicol, imatinib, isoniazid, nicardipine
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.