Drug interactions
Avanafil + Fosamprenavir
Severity: Contraindicated
Avanafil and Fosamprenavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (as amprenavir) inhibits CYP3A4 and can substantially increase avanafil levels. Adverse effects include severe hypotension, syncope, visual disturbance and priapism.
What this interaction means in plain words
Avanafil and Fosamprenavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
CYP3A4 inhibition decreases avanafil clearance.
What to do
Do not use together. Select an alternative treatment for erectile dysfunction.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Indinavir Contraindicated
Frequently asked questions
Can I take Avanafil with Fosamprenavir?
MediHelp rates the interaction as contraindicated. Avanafil and Fosamprenavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosamprenavir (as amprenavir) inhibits CYP3A4 and can substantially increase avanafil levels. Adverse effects include severe hypotension, syncope, visual disturbance and priapism.
How serious is the interaction between Avanafil and Fosamprenavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Select an alternative treatment for erectile dysfunction.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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