Drug interactions
Bupropion-naltrexone + Thioridazine
Severity: Contraindicated
Bupropion-naltrexone and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6 and can markedly raise thioridazine levels, increasing the risk of QT prolongation and torsades de pointes. Both drugs also lower the seizure threshold.
What this interaction means in plain words
Bupropion-naltrexone and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion-naltrexone belongs to Miscellaneous; Thioridazine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition raises thioridazine exposure; additive QT prolongation and lowered seizure threshold.
What to do
Avoid the combination; thioridazine is contraindicated with CYP2D6 inhibitors. Select an alternative antipsychotic with less QT and seizure liability.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bupropion-naltrexone and Thioridazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Thioridazine?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Bupropion inhibits CYP2D6 and can markedly raise thioridazine levels, increasing the risk of QT prolongation and torsades de pointes. Both drugs also lower the seizure threshold.
How serious is the interaction between Bupropion-naltrexone and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; thioridazine is contraindicated with CYP2D6 inhibitors. Select an alternative antipsychotic with less QT and seizure liability.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
