Drug reference
colchicine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Genitourinary (Anti Gout)
Mechanism of action
Gout: Disruption of cytoskeletal functions through inhibition of β-tubulin polymerization into microtubules, which prevents activation, degranulation, and migration of neutrophils. FMF: Mechanism not established;
Common side effects
- Fatigue
- Nausea
- Cramping
- Pharyngolaryngeal pain
- Abdominal pain
- Diarrhea
Contraindications
- Coadministration with P-gp or strong CY3A4 inhibitors in patients with hepatic or renal impairment Patients with both renal and hepatic impairment Coadministration with strong CYP3A4 inhibitors or P-glycoprotein inhibitors Patients with renal failure (CrCl <15 mL/minute) and severe hepatic…
Known interactions (30)
- clarithromycin + colchicine Contraindicated
- colchicine + ritonavir Contraindicated
- amiodarone + colchicine Major
- aprepitant + colchicine Major
- azithromycin + colchicine Major
- colchicine + cyclosporin Major
- colchicine + diltiazem Major
- colchicine + dronedarone Major
- colchicine + erythromycin Major
- colchicine + fluconazole Major
- colchicine + itraconazole Major
- colchicine + ketoconazole Major
- colchicine + mifepristone Major
- colchicine + posaconazole Major
- colchicine + quinidine Major
- colchicine + ribociclib Major
- colchicine + verapamil Major
- colchicine + voriconazole Major
- carvedilol + colchicine Moderate
- ciprofloxacin + colchicine Moderate
- colchicine + dasatinib Moderate
- colchicine + flibanserin Moderate
- colchicine + fluvoxamine Moderate
- colchicine + lapatinib Moderate
- colchicine + ledipasvir-sofosbuvir Moderate
- colchicine + quinine Moderate
- colchicine + ranolazine Moderate
- colchicine + rolapitant Moderate
- colchicine + sofosbuvir-velpatasvir Moderate
- colchicine + sofosbuvir-velpatasvir-voxilaprevir Moderate
Related conditions
Frequently asked questions
What drug class is colchicine?
colchicine belongs to: Genitourinary.
How does colchicine work?
Gout: Disruption of cytoskeletal functions through inhibition of β-tubulin polymerization into microtubules, which prevents activation, degranulation, and migration of neutrophils. FMF: Mechanism not established;
What are the common side effects of colchicine?
Fatigue, Nausea, Cramping, Pharyngolaryngeal pain, Abdominal pain, Diarrhea
Which drugs interact with colchicine?
clarithromycin, ritonavir, amiodarone, aprepitant, azithromycin, cyclosporin, diltiazem, dronedarone, erythromycin, fluconazole, itraconazole, ketoconazole, mifepristone, posaconazole, quinidine
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