Drug interactions
Clarithromycin + Dronedarone
Severity: Contraindicated
Clarithromycin and Dronedarone: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin increases dronedarone exposure and both drugs prolong the QT interval, creating a high risk of torsades de pointes. Strong CYP3A4 inhibitors are contraindicated with dronedarone.
What this interaction means in plain words
Clarithromycin and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Dronedarone belongs to Cardiovascular.
Why it happens
Strong CYP3A4 inhibition raises dronedarone levels, with additive QT prolongation.
What to do
Do not co-administer; use a non-interacting antibiotic. If clarithromycin is essential, hold dronedarone for the duration of therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Clarithromycin with Dronedarone?
MediHelp rates the interaction as contraindicated. Clarithromycin and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin increases dronedarone exposure and both drugs prolong the QT interval, creating a high risk of torsades de pointes. Strong CYP3A4 inhibitors are contraindicated with dronedarone.
How serious is the interaction between Clarithromycin and Dronedarone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-interacting antibiotic. If clarithromycin is essential, hold dronedarone for the duration of therapy.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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