Drug interactions
Duloxetine + Rasagiline
Severity: Contraindicated
Duloxetine and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an MAO inhibitor with an SNRI can cause serotonin syndrome and severe CNS toxicity with hyperthermia. Duloxetine labeling contraindicates use with MAO inhibitors, and rasagiline labeling advises against combining with antidepressants.
What this interaction means in plain words
Duloxetine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Duloxetine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
MAO-B inhibition (with reduced selectivity at higher doses) combined with serotonin and norepinephrine reuptake inhibition causes excess synaptic monoamines.
What to do
Do not coadminister. Allow at least 14 days after stopping rasagiline before starting duloxetine, and at least 5 days after stopping duloxetine before starting rasagiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Safinamide Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Rasagiline?
MediHelp rates the interaction as contraindicated. Duloxetine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAO inhibitor with an SNRI can cause serotonin syndrome and severe CNS toxicity with hyperthermia. Duloxetine labeling contraindicates use with MAO inhibitors, and rasagiline labeling advises against combining with antidepressants.
How serious is the interaction between Duloxetine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days after stopping rasagiline before starting duloxetine, and at least 5 days after stopping duloxetine before starting rasagiline.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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