Drug interactions
Insulin degludec-liraglutide + Megestrol
Severity: Moderate
Insulin degludec-liraglutide and Megestrol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Megestrol has glucocorticoid-like activity and can raise blood glucose, sometimes unmasking or worsening diabetes. This may reduce the effectiveness of insulin degludec and liraglutide.
What this interaction means in plain words
Insulin degludec-liraglutide and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Megestrol belongs to Oncology.
Why it happens
Progestin with glucocorticoid activity impairs glucose tolerance and insulin sensitivity.
What to do
Monitor blood glucose during megestrol therapy and increase antidiabetic doses if hyperglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Megestrol
- Dofetilide + Megestrol Contraindicated
- Insulin degludec / insulin aspart + Megestrol Moderate
- Insulin degludec-insulin aspart + Megestrol Moderate
- Insulin degludec + Megestrol Moderate
- Insulin inhaled + Megestrol Moderate
- Mavacamten + Megestrol Moderate
Frequently asked questions
Can I take Insulin degludec-liraglutide with Megestrol?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Megestrol has glucocorticoid-like activity and can raise blood glucose, sometimes unmasking or worsening diabetes. This may reduce the effectiveness of insulin degludec and liraglutide.
How serious is the interaction between Insulin degludec-liraglutide and Megestrol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during megestrol therapy and increase antidiabetic doses if hyperglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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