Drug interactions
Mavacamten + Megestrol
Severity: Moderate
Mavacamten and Megestrol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten may lower exposure to CYP3A4-metabolized hormonal agents, and labeling warns of reduced efficacy of hormonal contraceptives. Megestrol used for appetite or cancer is not mainly a contraceptive, so the clinical impact depends on use.
What this interaction means in plain words
Mavacamten and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mavacamten belongs to Cardiovascular; Megestrol belongs to Oncology.
Why it happens
Mavacamten may induce CYP3A4 and increase the metabolism of progestins.
What to do
If megestrol is used for contraception or hormonal therapy, add a nonhormonal method for the duration of mavacamten and for several months afterward. Monitor for loss of megestrol effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Megestrol
- Dofetilide + Megestrol Contraindicated
- Insulin degludec / insulin aspart + Megestrol Moderate
- Insulin degludec-insulin aspart + Megestrol Moderate
- Insulin degludec-liraglutide + Megestrol Moderate
- Insulin degludec + Megestrol Moderate
- Insulin inhaled + Megestrol Moderate
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Megestrol?
MediHelp rates the interaction as moderate. Mavacamten and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten may lower exposure to CYP3A4-metabolized hormonal agents, and labeling warns of reduced efficacy of hormonal contraceptives. Megestrol used for appetite or cancer is not mainly a contraceptive, so the clinical impact depends on use.
How serious is the interaction between Mavacamten and Megestrol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If megestrol is used for contraception or hormonal therapy, add a nonhormonal method for the duration of mavacamten and for several months afterward. Monitor for loss of megestrol effect.
What other medicines interact with Megestrol?
MediHelp also lists interactions of Megestrol with, for example, Dofetilide, Insulin degludec / insulin aspart, Insulin degludec-insulin aspart. The full list is on the Megestrol page.
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