Drug reference
dolasetron
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Gastrointestinal Tract (5-HT3 Antagonist)
Mechanism of action
Selective 5-HT3 receptor antagonist; dolasetron binds to 5-HT3 receptors located on vagal neurons in GI tract, blocking signal to vomiting center in the brain, thus preventing N/V.
Common side effects
- Dyspepsia
- Drowsiness
- Headache
- Fatigue
- Diarrhea
Contraindications
- Hypersensitivity Coadministration with apomorphine; combination reported to cause profound hypotension and loss of consciousness IV administration for chemotherapy-induced nausea/vomiting (CINV) because of risk for QT, PR, and QRS prolongation
Related conditions
Frequently asked questions
What drug class is dolasetron?
dolasetron belongs to: Gastrointestinal Tract.
How does dolasetron work?
Selective 5-HT3 receptor antagonist; dolasetron binds to 5-HT3 receptors located on vagal neurons in GI tract, blocking signal to vomiting center in the brain, thus preventing N/V.
What are the common side effects of dolasetron?
Dyspepsia, Drowsiness, Headache, Fatigue, Diarrhea
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