Drug interactions
Mefenamic acid + Pralatrexate
Severity: Major
Mefenamic acid and Pralatrexate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can delay renal elimination of pralatrexate, raising its exposure and the risk of toxicity such as mucositis and myelosuppression. Renal impairment further increases this risk.
What this interaction means in plain words
Mefenamic acid and Pralatrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mefenamic acid belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
Reduced renal clearance of pralatrexate through NSAID effects on renal perfusion and possibly competition for tubular secretion.
What to do
Monitor for pralatrexate toxicity (mucositis, cytopenias) and renal function, and avoid NSAIDs where possible. Adjust the pralatrexate dose according to toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Mefenamic acid with Pralatrexate?
MediHelp rates the interaction as major. Mefenamic acid and Pralatrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can delay renal elimination of pralatrexate, raising its exposure and the risk of toxicity such as mucositis and myelosuppression. Renal impairment further increases this risk.
How serious is the interaction between Mefenamic acid and Pralatrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pralatrexate toxicity (mucositis, cytopenias) and renal function, and avoid NSAIDs where possible. Adjust the pralatrexate dose according to toxicity.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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