Drug reference
azacitidine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Oncology (Anti Metabolite)
Mechanism of action
Pyrimidine analog of cytidine that inhibits DNA/RNA methyltransferases. Azacitidine is incorporated into RNA and DNA following cellular uptake and enzymatic biotransformation to nucleotide triphosphates. Hypomethylation of DNA and direct cytotoxic effect on abnormal hematopoietic cells in bone marrow.
Common side effects
- Constipation
- Neutropenia
- Anemia
- Vomiting
- Nausea
- Thrombocytopenia
- Pyrexia
Related conditions
Frequently asked questions
What drug class is azacitidine?
azacitidine belongs to: Oncology.
How does azacitidine work?
Pyrimidine analog of cytidine that inhibits DNA/RNA methyltransferases. Azacitidine is incorporated into RNA and DNA following cellular uptake and enzymatic biotransformation to nucleotide triphosphates. Hypomethylation of DNA and direct cytotoxic effect on abnormal hematopoietic cells in bone marrow.
What are the common side effects of azacitidine?
Constipation, Neutropenia, Anemia, Vomiting, Nausea, Thrombocytopenia, Pyrexia
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