Drug interactions
Lomitapide + Ribociclib
Severity: Contraindicated
Lomitapide and Ribociclib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate, and its exposure rises markedly with CYP3A4 inhibitors. Ribociclib, a moderate-to-strong CYP3A4 inhibitor, can increase the risk of lomitapide hepatotoxicity and gastrointestinal effects. Lomitapide labeling contraindicates moderate and strong CYP3A4 inhibitors.
What this interaction means in plain words
Lomitapide and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lomitapide belongs to Cardiovascular; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4 and markedly reduces lomitapide clearance.
What to do
Do not use together. If ribociclib is needed, hold lomitapide during treatment and monitor liver enzymes after restarting.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lomitapide and Ribociclib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Ribociclib?
MediHelp rates the interaction as contraindicated. Lomitapide and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lomitapide is a sensitive CYP3A4 substrate, and its exposure rises markedly with CYP3A4 inhibitors. Ribociclib, a moderate-to-strong CYP3A4 inhibitor, can increase the risk of lomitapide hepatotoxicity and gastrointestinal effects. Lomitapide labeling contraindicates moderate and strong CYP3A4 inhibitors.
How serious is the interaction between Lomitapide and Ribociclib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. If ribociclib is needed, hold lomitapide during treatment and monitor liver enzymes after restarting.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
