Drug interactions
carbamazepine + tramadol
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↓ analgesia + seizure risk.
Mechanism of action
CYP3A/2B6 induction; lowers tramadol/active metabolite.
Clinical management
Avoid; consider alternative analgesic.
Drug reference
References
Frequently asked questions
Can I take carbamazepine with tramadol?
The interaction is rated: Major. ↓ analgesia + seizure risk.
How serious is the interaction between carbamazepine and tramadol?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between carbamazepine and tramadol managed?
Avoid; consider alternative analgesic.
Why do carbamazepine and tramadol interact?
CYP3A/2B6 induction; lowers tramadol/active metabolite.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.