Drug interactions
Cyclobenzaprine + Tramadol
Severity: Major
Cyclobenzaprine and Tramadol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and has serotonergic activity. With tramadol it may raise the risk of serotonin syndrome and seizures, and add to sedation.
What this interaction means in plain words
Cyclobenzaprine and Tramadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclobenzaprine belongs to Musculoskeletal; Tramadol belongs to Musculoskeletal.
Why it happens
Additive serotonergic activity (reuptake inhibition) and lowered seizure threshold.
What to do
Avoid the combination when possible, and use a non-serotonergic muscle relaxant or analgesic. If used together, monitor for agitation, tremor, hyperthermia and clonus.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Tramadol?
MediHelp rates the interaction as major. Cyclobenzaprine and Tramadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclobenzaprine is structurally related to tricyclic antidepressants and has serotonergic activity. With tramadol it may raise the risk of serotonin syndrome and seizures, and add to sedation.
How serious is the interaction between Cyclobenzaprine and Tramadol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible, and use a non-serotonergic muscle relaxant or analgesic. If used together, monitor for agitation, tremor, hyperthermia and clonus.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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