Drug interactions
Acetazolamide + Sulphasalazine
Severity: Minor
Acetazolamide and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acetazolamide can raise salicylate concentrations in the plasma and brain at moderate doses and may cause acidosis. Sulfasalazine's salicylate exposure is low, so effects are mainly relevant at high doses or with renal impairment.
What this interaction means in plain words
Acetazolamide and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetazolamide belongs to Miscellaneous; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Competition for renal tubular secretion and altered urinary pH and acid-base status shifting salicylate distribution.
What to do
Monitor for CNS symptoms such as confusion or drowsiness, acid-base status and renal function, particularly in elderly or renally impaired patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Acetazolamide and Sulphasalazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Acetazolamide
Frequently asked questions
Can I take Acetazolamide with Sulphasalazine?
MediHelp rates the interaction as minor. Acetazolamide and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Acetazolamide can raise salicylate concentrations in the plasma and brain at moderate doses and may cause acidosis. Sulfasalazine's salicylate exposure is low, so effects are mainly relevant at high doses or with renal impairment.
How serious is the interaction between Acetazolamide and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS symptoms such as confusion or drowsiness, acid-base status and renal function, particularly in elderly or renally impaired patients.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
