Drug interactions
Adalimumab + Hydroxycarbamide
Severity: Moderate
Adalimumab and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyurea suppresses the bone marrow and adalimumab blocks TNF-alpha. Together they may increase the risk of infection and cytopenias.
What this interaction means in plain words
Adalimumab and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Adalimumab belongs to Musculoskeletal; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression.
What to do
Monitor complete blood counts and signs of infection regularly. Adjust hydroxyurea dose for cytopenias and hold adalimumab during serious infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Adalimumab
- Adalimumab + Bcg vaccine live Contraindicated
- Adalimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Adalimumab + Measles mumps and rubella vaccine live Contraindicated
- Adalimumab + Measles mumps rubella and varicella vaccine live Contraindicated
- Adalimumab + Measles vaccine Contraindicated
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Adalimumab with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Adalimumab and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyurea suppresses the bone marrow and adalimumab blocks TNF-alpha. Together they may increase the risk of infection and cytopenias.
How serious is the interaction between Adalimumab and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of infection regularly. Adjust hydroxyurea dose for cytopenias and hold adalimumab during serious infection.
What other medicines interact with Adalimumab?
MediHelp also lists interactions of Adalimumab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Adalimumab page.
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