Drug interactions
Alprazolam + Metoclopramide
Severity: Moderate
Alprazolam and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause sedation and drowsiness, and alprazolam adds to CNS depression. Metoclopramide may also modestly speed absorption of some benzodiazepines, increasing peak effects.
What this interaction means in plain words
Alprazolam and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alprazolam belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression, with possible faster benzodiazepine absorption from accelerated gastric emptying.
What to do
Counsel patients about drowsiness and impaired psychomotor performance. Use the lowest effective doses and monitor sedation, especially in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Alprazolam + Sodium oxybate Contraindicated
- Alfentanil + Alprazolam Major
Frequently asked questions
Can I take Alprazolam with Metoclopramide?
MediHelp rates the interaction as moderate. Alprazolam and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause sedation and drowsiness, and alprazolam adds to CNS depression. Metoclopramide may also modestly speed absorption of some benzodiazepines, increasing peak effects.
How serious is the interaction between Alprazolam and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and impaired psychomotor performance. Use the lowest effective doses and monitor sedation, especially in elderly patients.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine. The full list is on the Metoclopramide page.
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