Drug reference
metoclopramide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Gastrointestinal Tract (Prokinetic)
Mechanism of action
Blocks dopamine receptors (at high dose) and serotonin receptors in chemoreceptor trigger zone of CNS; and sensitizes tissues to acetylcholine; increases upper GI motility but not secretions; increases lower esophageal sphincter tone.
Common side effects
- Extrapyramidal symptoms
- Restlessness
- Sedation
- Fatigue
Contraindications
- Hypersensitivity to metoclopramide or procainamide History of tardive dyskinesia (TD) or a dystonic reaction to metoclopramide When stimulation of gastrointestinal motility might be dangerous (e.g., in the presence of gastrointestinal hemorrhage, mechanical obstruction, or perforation) Pre…
Known interactions (3)
Related conditions
Frequently asked questions
What drug class is metoclopramide?
metoclopramide belongs to: Gastrointestinal Tract.
How does metoclopramide work?
Blocks dopamine receptors (at high dose) and serotonin receptors in chemoreceptor trigger zone of CNS; and sensitizes tissues to acetylcholine; increases upper GI motility but not secretions; increases lower esophageal sphincter tone.
What are the common side effects of metoclopramide?
Extrapyramidal symptoms, Restlessness, Sedation, Fatigue
Which drugs interact with metoclopramide?
antipsychotics (e.g., haloperidol), cabergoline, dopamine
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