Drug interactions
Alteplase + Celecoxib
Severity: Moderate
Alteplase and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alteplase dissolves clots, and an NSAID can add to the bleeding tendency. Celecoxib has less platelet effect than non-selective NSAIDs, but bleeding risk, including gastrointestinal, may still rise.
What this interaction means in plain words
Alteplase and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alteplase belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
Thrombolysis combined with NSAID-related mucosal injury and some effect on hemostasis increases bleeding potential.
What to do
Assess bleeding risk before thrombolysis and monitor for bleeding during and after treatment. Avoid starting NSAIDs unnecessarily in the period afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Celecoxib?
MediHelp rates the interaction as moderate. Alteplase and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alteplase dissolves clots, and an NSAID can add to the bleeding tendency. Celecoxib has less platelet effect than non-selective NSAIDs, but bleeding risk, including gastrointestinal, may still rise.
How serious is the interaction between Alteplase and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess bleeding risk before thrombolysis and monitor for bleeding during and after treatment. Avoid starting NSAIDs unnecessarily in the period afterward.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Aceclofenac, Acemetacin, Amiloride. The full list is on the Celecoxib page.
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