Drug interactions
Alteplase + Dalteparin
Severity: Major
Alteplase and Dalteparin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dalteparin given with alteplase increases the risk of major bleeding, including intracranial hemorrhage. Co-administration is sometimes intended, but the bleeding risk remains high.
What this interaction means in plain words
Alteplase and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alteplase belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect of fibrinolysis from alteplase and anti-Xa anticoagulation from dalteparin.
What to do
Co-administer only when clearly indicated and follow the protocol for dose and timing. Monitor closely for bleeding, hemoglobin and neurological status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Alteplase and Dalteparin interact, what to do about it, and the sources.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dalteparin
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Alteplase
- Alteplase + Defibrotide Contraindicated
- Alteplase + Reteplase Contraindicated
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Alteplase Major
- Alteplase + Apixaban Major
- Alteplase + Argatroban Major
Frequently asked questions
Can I take Alteplase with Dalteparin?
MediHelp rates the interaction as major. Alteplase and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dalteparin given with alteplase increases the risk of major bleeding, including intracranial hemorrhage. Co-administration is sometimes intended, but the bleeding risk remains high.
How serious is the interaction between Alteplase and Dalteparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Co-administer only when clearly indicated and follow the protocol for dose and timing. Monitor closely for bleeding, hemoglobin and neurological status.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Abciximab, Acalabrutinib, Aceclofenac. The full list is on the Dalteparin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
