Drug interactions
Aluminum hydroxide + Amlodipine-perindopril
Severity: Minor
Aluminum hydroxide and Amlodipine-perindopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids may modestly reduce the absorption of some ACE inhibitors, which could blunt the blood pressure response. The effect for perindopril is not well characterized and is likely small.
What this interaction means in plain words
Aluminum hydroxide and Amlodipine-perindopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aluminum hydroxide belongs to Gastrointestinal Tract; Amlodipine-perindopril belongs to Cardiovascular.
Why it happens
Possible reduced gastrointestinal absorption of the ACE inhibitor when taken with antacids; the mechanism is not firmly established.
What to do
Separate the antacid from perindopril by about two hours and monitor blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Amlodipine-perindopril?
MediHelp rates the interaction as minor. Aluminum hydroxide and Amlodipine-perindopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids may modestly reduce the absorption of some ACE inhibitors, which could blunt the blood pressure response. The effect for perindopril is not well characterized and is likely small.
How serious is the interaction between Aluminum hydroxide and Amlodipine-perindopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the antacid from perindopril by about two hours and monitor blood pressure.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Amifostine, Amiloride. The full list is on the Amlodipine-perindopril page.
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