Drug reference
amlodipine-perindopril
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Perindopril: A prodrug that is hydrolyzed to perindoprilat; inhibits angiotensin-converting enzyme (ACE) that initially results in decreased plasma angiotensin II concentrations, and, consequently, blood pressure may be reduced. Amlodipine: A dihydropyridine calcium antagonist; it inhibits transmembrane influx of extracellular calcium
Common side effects
- Dizziness
- Headache
- Cough
- Peripheral edema
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- History of hereditary or acquired angioedema associated with previous ACE inhibitor treatment Coadministration of neprilysin inhibitors (eg, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors within 36 hr of switching to or from sacubitril/valsartan…
Known interactions (1)
- amlodipine-perindopril + dantrolene Moderate
Related conditions
Frequently asked questions
What drug class is amlodipine-perindopril?
amlodipine-perindopril belongs to: Cardiovascular.
How does amlodipine-perindopril work?
Perindopril: A prodrug that is hydrolyzed to perindoprilat; inhibits angiotensin-converting enzyme (ACE) that initially results in decreased plasma angiotensin II concentrations, and, consequently, blood pressure may be reduced. Amlodipine: A dihydropyridine calcium antagonist; it inhibits transmembrane influx of extracellular calcium
What are the common side effects of amlodipine-perindopril?
Dizziness, Headache, Cough, Peripheral edema
Which drugs interact with amlodipine-perindopril?
dantrolene
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