Drug interactions
Aluminum hydroxide + Sulphasalazine
Severity: Minor
Aluminum hydroxide and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids that alter urinary pH could change renal excretion of salicylate, but the amount of salicylate from sulfasalazine is small. Clinically relevant effects are unlikely.
What this interaction means in plain words
Aluminum hydroxide and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aluminum hydroxide belongs to Gastrointestinal Tract; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Theoretical urinary alkalinisation altering salicylate tubular reabsorption.
What to do
No specific action needed. Review if the patient has unexplained changes in response to sulfasalazine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Sulphasalazine?
MediHelp rates the interaction as minor. Aluminum hydroxide and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids that alter urinary pH could change renal excretion of salicylate, but the amount of salicylate from sulfasalazine is small. Clinically relevant effects are unlikely.
How serious is the interaction between Aluminum hydroxide and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action needed. Review if the patient has unexplained changes in response to sulfasalazine.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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