Drug interactions
Amantadine + Solifenacin
Severity: Moderate
Amantadine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amantadine has anticholinergic properties that can add to solifenacin's antimuscarinic effects. Patients may experience confusion, hallucinations, dry mouth, constipation, and urinary retention, especially if elderly.
What this interaction means in plain words
Amantadine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Solifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for confusion, urinary retention, and constipation. Reduce doses or choose an alternative if anticholinergic toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Solifenacin?
MediHelp rates the interaction as moderate. Amantadine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amantadine has anticholinergic properties that can add to solifenacin's antimuscarinic effects. Patients may experience confusion, hallucinations, dry mouth, constipation, and urinary retention, especially if elderly.
How serious is the interaction between Amantadine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for confusion, urinary retention, and constipation. Reduce doses or choose an alternative if anticholinergic toxicity develops.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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