Drug interactions
Ambrisentan + Sofosbuvir-velpatasvir
Severity: Minor
Ambrisentan and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits OATP transporters, which contribute to ambrisentan hepatic uptake. Ambrisentan exposure may rise modestly, increasing dose-related adverse effects such as edema, headache and anemia.
What this interaction means in plain words
Ambrisentan and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir inhibits OATP1B1, OATP1B3 and OATP2B1, reducing hepatic uptake of ambrisentan.
What to do
No empiric dose change is required; monitor for peripheral edema and hemoglobin changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Ambrisentan and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits OATP transporters, which contribute to ambrisentan hepatic uptake. Ambrisentan exposure may rise modestly, increasing dose-related adverse effects such as edema, headache and anemia.
How serious is the interaction between Ambrisentan and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is required; monitor for peripheral edema and hemoglobin changes.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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