Drug interactions
Ambrisentan + Tolvaptan
Severity: Minor
Ambrisentan and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein in vitro and could modestly raise exposure to ambrisentan, which is a P-gp substrate. A clinically meaningful effect has not been established.
What this interaction means in plain words
Ambrisentan and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Tolvaptan belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein mediated efflux by tolvaptan, potentially increasing ambrisentan exposure.
What to do
No dose change is routinely required. Monitor for ambrisentan adverse effects such as edema, headache and anemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Tolvaptan?
MediHelp rates the interaction as minor. Ambrisentan and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein in vitro and could modestly raise exposure to ambrisentan, which is a P-gp substrate. A clinically meaningful effect has not been established.
How serious is the interaction between Ambrisentan and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required. Monitor for ambrisentan adverse effects such as edema, headache and anemia.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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